When and how should we cluster and cross over: methodological and ethical issues

Violence against Women: Methodological and Ethical Issues

Research on violence against women has improved and provides important information on patterns, prevalence, risk and consequences of this major threat to female well-being. Since the identification of violence against women as a problem worthy of study in 1970, evident progress has been made in understanding physical, psychological and sexual violence against women. However, while methodologica...

Cluster randomised trials : Methodological and ethical considerations

Prosthetic valve thrombosis: when and how should we lyse?

Ö o ( c p e fi ( ( t d v ( l With the advent of the Starr-Edwards mechanical mitral and aortic valves in the 1960s, the surgical era of the treatment of cardiac valvular disease began in earnest. Although considered definitive, valve replacement surgery effectively represents an exchange of the pathophysiology of severe valvular dysfunction for the diseases and complications associated with pro...

When and how far should we lower blood pressure?

The accuracy of the diagnosis of mild or borderline hypertension is dubious. Perhaps up to one-third of such patients are wrongly categorized when more accurate measures are taken, largely because of the "defense" reaction. The recent trials of mild hypertension are discussed. Patients with a diastolic blood pressure in the range of 95 to 100 mm Hg should only begin treatment after careful asse...

fluoride and dental fluorosis and treatment

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